IAS Mains Previous Years Paper : Medical Sciences (1999)

PAPER - I
1. Answer any three of the following (each in about 200 words) :
(a) Describe the development of rights and left Atria. Mention the cogenital malformations associated with its development. (20)
(b) Mention different ways by which enzyme activity is regulated. Describe the regulatory steps of glycolysis. (20)
(c) Discuss briefly immune response to Virus Infection. (20)
(d) Classify diuretics. Discuss the dosage and route of administration of Furosemide in different clinical conditions. (20)
(e) A person is having 24 teeth of which 20 are milk teeth. Answer with reasons what is the age of the person. (20)
(f) Describe the aetiopathogenesis of chronic hepatitis. (20)

SECTION A
(Anatomy, Physiology & Biochemistry)
2. (a) Write short notes on :
(i) Development of uterus and its congenital anomalies.
(ii) Distribution of facial nerve. (10 + 10 = 20)

(b) Discuss the mechanism of action of Hormones. (20)
(c) Explain why toxicity of vitamins is seen mainly with respect to fat soluble vitamins only. Describe different forms and roles of vitamin A. (20)

3. (a) Write short notes on :
(i) Broncho-pulmonary segments of lungs.
(ii) Mechanism of locking and unlocking of knee joint. (10 + 10 = 20)

(b) (i) Describe the structure and functions of muscle spindle.
(ii) Compare the properties of monosynaptic and polysynaptic reflexes. (10 + 10 = 20)
(c) Name the enzymes involved in DNA and RNA synthesis. Describe post-transcriptional modifications. (20)

SECTION B
(Pathology & Microbiology)
4. (a) Discuss pathogenesis and pathology of ischaemic heart disease. (30)
(b) Discuss pathogenesis and laboratory diagnosis of Cholera. (30)

5. (a) Describe carcinoma colon. Name its pre-cancerous conditions. (30)
(b) Name various parasites which may be found in the peripheral blood. Discuss briefly life cycle, pathogenicity and laboratory diagnosis of Plasmodium Falciparum (30)

SECTION C
(Pharmacology Forensic Medicine & Toxicology)
6. (a) Describe the mechanism of action and adverse effects of narcotic analgesics. (20)
(b) Describe the mechanism of action, dosage and toxicity of ampicillin. (20)
(c) Discuss adverse effects of the following drugs.
(i) Chloroquin
(ii) Metronidazole
(iii) Methotrexate
(iv) Aspirin (20)

7. (a) A skull has been sent to you for examination. How will you determine the sex and establish the individual identity? (40)
(b) How will you differentiate an entry wound from an exit wound in case of a firearm injury?(20)

PAPER - II
1. Write short notes on any three of the following (each in about 200 words) : (3 x 20 = 60)
(a) Schizophrenia
(b) Complications of Ulcerative Colitis
(c) Diagnosis and management of Traumatic Post Partum Hemorrhage (RRH.)
(d) Uses of Cohert studies in Epidemiology

SECTION A
(General Medicine)
2. Describe the clinical features, investigations and management of Acute Myocardial Infarction. (60)

3. (a) How will you diagnose iron deficiency anaemia? (20)
(b) What are the clinical features, diagnosis and treatment of Chronic Pyelonephritis? (20)
(c) Discuss the management of Acute Pyogenic Meningitis. (20)

SECTION B
(General Surgery)
4. Describe the pathology and management of Ilececal Tuberculosis. (60)

5. (a) Discuss the pathogenesis and treatment of Breast Abscess. (20)
(b) Describe the pathology and outline of diagnostic modalities of solitary module of thyroid. (20)
(c) Classify the types of extra-capsular fractures of Proximal Femur and describe the treatment of trochanteric fractures. (20)

SECTION C
(Obstetric and Gynecology including Family Planning)
6. Describe the etiology, clinical features and management of ruptures uterus. (60)

7. (a) What are I.U.C.D.s ? Discuss Cu-T in detail? (20)
(b) What are the main objectives of A.N.C. (Ante-natal Care)? Mention in detail about regular A.N.C? (20)
(c) Discuss placenta previa in detail. (20)

SECTION D
(Preventive and Social Medicine)
8. Discuss the multi-factorial etiology, resulting in malaria. List the steps in the control of malignant malaria. (60)

9. (a) Discuss the prevention and treatment of Kala-azar. (20)
(b) What are the health hazards of coal miners in open cast and underground mines? (20)
(c) Describe the causes associated with cancer cervix and cancer breast, among women 40 years and above. (20)