(The Gist of Science Reporter) Nanozymes that can block HIV reactivation
(GIST OF SCIENCE REPORTER) Nanozymes that can block HIV reactivation
Nanozymes that can block HIV reactivation
Researchers at the Indian Institute of Science (IISc) have developed artificial enzymes that can successfully block reactivation and replication of the Human Immunodeficiency Virus (HIV) in the host’s immune cells.
Made from vanadium pentoxide nanosheets, these “nanozymes” work by mimicking a natural enzyme called glutathione peroxidase that helps reduce oxidative stress levels in the host’s cells, which is required to keep the virus in check.
The researchers prepared ultrathin nanosheets of vanadium pentoxide in the lab and treated HIV-infected cells with them. The sheets were found to reduce hydrogen peroxide just as effectively as the natural enzyme and prevent the virus from reactivating.
Combining ART with the nanozymes also has other advantages.
Some ART drugs can cause oxidative stress as a side effect, which can damage heart or kidney cells.
Adding a nanozyme like this can help in reducing the side effects caused by such ART drugs. This can improve the quality of life of HIV patients undergoing treatment.