India and Israel celebrate 25 years of their diplomatic relations
As India and Israel celebrate 25 years of their diplomatic relations,
Tel Aviv has quietly emerged as one of the largest and trusted suppliers of
defence equipment to the Indian armed forces, which rely heavily on imports.
After protracted negotiations, the two countries are close to concluding
a deal for Spike Anti-Tank Guided Missiles. This will be the latest in a
series of big-ticket defence deals approved recently.
The purchase of Spike missiles was approved by the Defence Acquisition
Council (DAC) in October 2014, but negotiations on the contract ran into
trouble over cost and technology transfer.
The Rs. 3,200-crore deal includes 8,000-plus missiles, 300-plus
launchers and technology transfer. The deal is likely to expand as the Army
intends to equip its 382 infantry battalions and 44 mechanised regiments
with new missiles.
After New Delhi established full diplomatic ties with Tel Aviv on
January 29, 1992, Israel has made inroads into the Indian defence sector,
earning praise for reliability and technological sophistication.
It is well entrenched in the areas of Unmanned Aerial Vehicles, air
defence systems, special forces equipment and electronic warfare equipment.
Cabinet Committee on Security (CCS) approved a Rs. 17,000-crore deal to
jointly develop a Medium Range Surface to Air Missile (MR-SAM) system for
In the case of mouse models, the 5g molecule was able to arrest tumour
growth without causing significant side-effects.
The inhibitor was able to arrest the cancer cells from proliferating by
elevating the levels of intracellular reactive oxygen species (ROS), which,
in turn, causes DNA damage by breaking the DNA’s double-strands.
The molecule also activated the cell death pathway when higher
concentration was used. However, the molecule did not cause any damage to
normal blood cells. The results were published in the journal Scientific
At a dosage of 50 micromolar, about 70% of leukaemia cells were killed,
compared with 25% of normal blood cells. This suggests that the 5g molecule
could be “less toxic” to normal cells compared with cancer cells.
Even when the dosage was reduced to 10 micromolar, the molecule was able
to arrest the cell cycle, particularly after 36 hours of treatment.
However, at the end of 48 hours, the cells were either dead or repaired
their DNA damage and proceeded with normal cell cycle of division and
A majority of the cancer cells were killed but some reverted to normal
cell cycle. The reason for this is not known.
In mouse models, the molecule was able to arrest cancer cells’ cell
cycle when 60 and 120 mg per kg of body weight dosages were used. Also,
“significant” reduction in tumour volume and “moderate” increase in
life-span were observed when treated with 60 mg per kg of body weight for 14
days. The molecule was able to reduce the tumour burden by arresting the
cell cycle than by causing cell death, the researchers found.
Since on its own the molecule did not bring about cell death in mouse
models, it cannot be used as a standalone therapy.
Highly protected marine reserves can help mitigate the effects of climate
Evaluating 145 peer-reviewed studies, a research team has concluded that
“highly protected” marine reserves can help mitigate the effects of climate
Around the world, coastal nations have committed to protecting 10% of
their waters by 2020, but so far, only 3.5% of the ocean has been set aside
for protection, and 1.6%, or less than half of that, is strongly protected
from exploitation, Xinhua reported.
The study also notes that ocean surface waters have become on average
26% more acidic since pre-industrial times.
By the year 2100, under a “business-as-usual” scenario, they will be
150% more acidic, while coastal wetlands, including mangroves, seagrasses
and salt marshes have demonstrated a capacity for reducing local carbon
dioxide concentrations because many contain plants with high rates of