(The Gist of PIB) Ber-D  [MAY-2020]

(The Gist of PIB) Ber-D

Ber-D

• Scientists from Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) have modified the structure of Berberine into Ber-D to use as an Alzheimer’s inhibitor.

About: 

• Alzheimer’s disease is the most prevalent neurodegenerative disorder and accounts for more than 70% of all dementia. The multifactorial nature of the disease attributed to multifaceted toxicity has made it difficult for researchers to develop effective medication.
• Berberine is poorly soluble and toxic to cells. So they modified berberine to Ber-D, which is a soluble (aqueous), antioxidant. They found it to be a multifunctional inhibitor of multifaceted amyloid toxicity of Alzheimer’s disease.
• The structural attributes of Ber-D are such that they prevent the generation of reactive oxygen species (ROS) and rescue biomacromolecules from oxidative damage.

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Courtesy: PIB