(GIST OF SCIENCE REPORTER) DANGER : Software Tool For Genome Editing

(DECEMBER-2023)

DANGER : Software Tool For Genome Editing

• DANGER analysis is a new software tool that makes genome editing safer by overcoming limitations in current CRISPR technology.
• Unlike traditional methods that rely on a reference genome, DANGER works by conducting risk-averse on- and off-target assessments using RNA-sequencing data.

About:

• It evaluates phenotypic effects based on gene expression changes caused by deleterious off-target sites.
• The software quantifies the phenotypic risk at the gene ontology level without the need for a reference genome.
• The tool successfully evaluated the phenotypic effects of gene editing in human cells and zebrafish brains.
• It can be performed on various organisms, personal human genomes, and atypical genomes created by diseases and viruses.
• The open-source nature of the software allows for its adaptation to different genome editing systems beyond CRISPR-Cas9.

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Courtesy: Science Reporter