UPSC Mains Exam Syllabus - Medical Science Optional
PAPER - I:
1. Human Anatomy:
Applied anatomy including blood and
nerve supply of upper and lower limbs and
joints of shoulder, hip and knee.
Gross anatomy, blood supply and lymphatic
drainage of tongue, thyroid, mammary
gland, stomach, liver, prostate, gonads
Applied anatomy of diaphragm, perineum
and inguinal region.
Clinical anatomy of kidney, urinary bladder,
uterine tubes, vas deferens.
Embryology: Placenta and placental barrier.
Development of heart, gut, kidney,
uterus, ovary, testis and their common congenital
Central and peripheral autonomic nervous
system : Gross and clinical anatomy
of ventricles of brain, circulation of cerebrospinal
fluid; Neural pathways and lesions
of cutaneous sensations, hearing and
vision; Cranial nerves, distribution and clinical significance; Components of autonomic
2. Human Physiology:
Conduction and transmission of impulse,
mechanism of contraction, neuromuscular
transmission, reflexes, control of equilibrium,
posture and muscle tone, descending
pathways, functions of cerebellum,
basal ganglia, Physiology of sleep and
Endocrine system: Mechanism of action
of hormones, formation, secretion, transport, metabolism, function and regulation
of secretion of pancreas and pituitary gland.
Physiology of reproductive system: Menstrual
cycle, lactation, pregnancy.
Blood: Development, regulation and fate
of blood cells.
Cardio-vascular, cardiac output, blood
pressure, regulation of cardiovascular
3. Biochemistry: Organ function tests-liver, kidney, thyroid
Vitamins and minerals.
Restriction fragment length polymorphism
Polymerase chain reaction (PCR).
Radio - immunoassays (RIA).
Inflammation and repair, disturbances of
growth and cancer, Pathogenesis and histopathology
of rheumatic and ischemic heart disease and diabetes mellitus. Differentiation
between benign, malignant,
primary and metastatic malignancies,
Pathogenesis and histopathology of bronchogenic
carcinoma, carcinoma breast,
oral cancer, cancer cervix, leukemia, Etiology,
pathogenesis and histopathology of -
cirrhosis liver, glomerulonephritis, tuberculosis,
Humoral and cell mediated immunity
Diseases caused by and laboratory diagnosis
l Meningococcus, Salmonella
l Shigella, Herpes, Dengue, Polio
l HIV/AIDS, Malaria, E. Histolytica, Giardia
l Candida, Cryptococcus, Aspergillus
6. Pharmacology: Mechanism of action and side effects of
the following drugs
l Antipyretics and analgesics, Antibiotics,
l Antihypertensive, Antidiuretics, General
and cardiac vasodilators, Antiviral, Antiparasitic,
7. Forensic Medicine and Toxicology:
Forensic examination of injuries and
wounds; Examination of blood and seminal stains; poisoning, sedative overdose,
hanging, drowning, burns, DNA and finger
PAPER - II:
1. General Medicine:
Etiology, clinical features, diagnosis and
principles of management (including prevention)
of: - Tetanus, Rabies, AIDS, Dengue,
Kala-azar, Japanese Encephalitis.
Etiology, clinical features, diagnosis and
principles of management of:
Ischaemic heart disease, pulmonary embolism.
Pleural effusion, tuberculosis, Malabsorption
syndromes, acid peptic diseases, Viral
hepatitis and cirrhosis of liver.
Glomerulonerphritis and pyelonephritis,
renal failure, nephrotic syndrome, renovascular
hypertension, complications of diabetes
mellitus, coagulation disorders, leukemia,
Hypo and hyper thyrodism, meningitis
Imaging in medical problems, ultrasound,
echocardiogram, CT scan, MRI.
Anxiety and Depressive Psychosis and
schizophrenia and ECT.
Immunization, Baby friendly hospital, congenital
cyanotic heart disease, respiratory
distress syndrome, broncho - pneumonias,
kernicterus. IMNCI classification and management,
PEM grading and management.
ARI and Diarrhea of under five and their
Psoriasis, Allergic dermatitis, scabies, eczema,
vitiligo, Stevan Johnson’s syndrome,
4. General Surgery:
Clinical features, causes, diagnosis and
principles of management of cleft palate,
Laryngeal tumor, oral and esophageal
Peripheral arterial diseases, varicose
veins, coarctation of aorta
Tumors of Thyroid, Adrenal Glands
Abscess, cancer, fibroadenoma and
adenosis of breast.
Bleeding peptic ulcer, tuberculosis of
bowel, ulcerative colitis, cancer stomach.
Renal mass,cancer Prostate..
Haemothorax, stones of Gall bladder, Kidney,
Ureter and Urinary Bladder.
Management of surgical conditions of Rectum,
Anus and Anal canal, Gall bladder
and Bile ducts
Splenomegaly, cholecystitis, portal hypertension,
liver abscess, peritonitis, carcinoma
head of pancreas.
Fractures of spine, Colles’ fracture and
5. Obstetrics and Gynaecology including
Diagnosis of pregnancy.
Labour management, complications of 3rd
stage, Antepartum and postpartum hemorrhage,
resuscitation of the newborn,
Management of abnormal lie and difficult
labour, Management of small for date or
Diagnosis and management of anemia.
Preeclampsia and Toxaemias of pregnancy,
Management of Post menopausal
Intra-uterine devices, pills, tubectomy and
vasectomy. Medical termination of pregnancy
including legal aspects.
Leucorrhoea, pelvic pain, infertility, dysfunctional
uterine bleeding (DUB), amenorrhoea,
Fibroid and prolapse of uterus.
6. Community Medicine (Preventive and
Social Medicine): Principles, methods, approach and measurements
Nutrition, nutritional diseases / disorders &
Health information Collection, Analysis and
Objectives, components and critical analysis
of National programmes for control/
Malaria, Kala-azar, Filaria and Tuberculosis,HIV/AIDS, STDs and Dengue
Critical appraisal of Health care delivery
Health management and administration: Techniques, Tools, Programme Implementation
Objective, Component, Goals and Status
of Reproductive and Child Health, National
Rural Health Mission and Millennium Development
Management of hospital and industrial