Maharashtra PSC:
Medical Science : Revised Syllabus for State Services (Main) Examination
(Optional)
Medical Sciences (Code No : 701)
Paper - I
Standard : MBBS Degree
Total Marks : 200
Nature of Paper : Conventional Type
Duration : 3 Hours
Note:
1) Answers to this paper must be written in English only.
2) This paper will test the candidate’s ability to comprehend, to analyse, to
interpret, to criticise and to appraise the subject matter related to the
topics/sub topics mentioned below.
3) It is expected from candidates to study the latest and recent developments
and happenings pertaining to the topics/sub topics mentioned below.
Section - A ( Marks : 50 )
1) HUMAN ANATOMY :
1) General Anatomy - Bone, Joints, Muscles, Cartilage,
integument & Skin, Appendages, fascia, Blood Vessels, lymphatics, Neurology.
2) Regional Anatomy -
a) Upper limb : Joints, arteries,
veins, lymphatics, bones, muscles and nerves of Upper limb with applied anatomy.
Mammary gland, axilla, cubital fossa brachial plexus.
b) Lower limb : Joints, arteries,
veins, lymphatics, bones, muscles and nerves of Lower limb with applied, anatomy
femoral triangle; adductor canal, popliteal fossa, sole, arches of foot, gluteal
region.
c) Abdomen and thorax : Joints,
arteries, veins, lymphatics, bones, muscles and nerves , Anterior abdominal
wall, quadrants, peritoneum, Anatomy of thoracic and pelvic diaphragm with its
applied, anatomy Thoracic wall, thoracic inlet, outlet, intercostal space,
mediastinum, pleura. pericardium and heart.
d) Head - face and neck : triangles
of neck, oral and Nasal Cavity, Salivary glands, face, scalp, larynx, pharynx,
orbit, eyeball, ear, spinal cord, CSF, meninges and Brain.
2) Histology :
1) General Histology - cell, cell organelles-nucleus
chromatin. Epithelial- Cilia; Microvilli; Stereocilia; Glands, Connective
tissue. Bone - Cartilage. Neurons and Neuroglia, Blood vessels, Lymphoid tissue.
2) Systemic histology - skin and its appendages, lip, tongue;
tooth, salivary glands; G.I. Tract with glands, Respiratory system, Urinary
system, Male and Female reproductive system, Endocrine glands, nerves system,
Cornea; Sclerocorneal junction; Lens; Retina; Optic nerve. Cochlea.
3) Embryology :
1) General embryology -
Gametogenesis: reproductive cycles, Fertilisation, Contraception, Sex
determination, “Sex-ratio”, Cleavages, Implantation and development of embryo,
Foetal membranes, Allantois, Derivatives of germ layers, Decidua; Umbilical
cord; Foetomaternal circulation.
2) Systemic Embryology - Development
of Cardio-vascular system, Respiratory system, Gastrointestinal system with
related glands, Unriary system, Male and Female reproductive system. Skin and
appendages. Pharyngeal arches, Development of face, palate, endocrine glands.
Spinal Cord and Brain, Forebrain, Midbrain and Hindbrain, Peripheral Nervous
System. - Eye and Ear.
4) GENETICS : Mendelism, Eugenics, Sex chromatin, Population genetics
Cytogenetics, Cell cycle, Molecular genetics Gene, Genetic code, DNA, RNA.
Inheritance : Pedigree charts. Mutation, Polymorphism, Lyon’s hypothesis;
teratogenesis. Chromosomal abnormalities, Prenatal diagnosis. Karyotype and
genetic counselling. Clinical genetics.
Section - B ( Marks : 50 )
5) HUMAN PHYSIOLOGY :
1) General physiology and hematology - Homeostasis,
Biofeedback mechanisms. Cell Physiology, Blood : Plasma proteins, anaemia,
polycythemia. Haemopoiesis, Immunity : Blood groups, Hemostasis and
Anticoagulants, Body fluid compartments, Blood volume. Bone marrow,
Haemoglobinopathies, haemorrhagic diseases.
2) Respiratory physiology and Cardiovascular physiology -
Physiology of respiratory system, Mechanics of respiration, dead space,
Diffusion of Gases, Transport of oxygen and carbondioxide, Control of Breathing,
Hypoxia, Artificial respiration, Pulmonary function tests. Properties of cardiac
muscle heart, pacemaker, ECG ,Cardiac cycle. Haemodynamics, cardiac output,
Blood pressure, Capillary circulation, tissue fluid, lymphatic system, Regional
circulation.
3) Renal physiology, Body temperature regulation - kidney,
Renal circulation, Concept of clearance, Formation of urine, acid-base balance.
Physiology of micturition, Artificial kidney, dialysis, Regulation of body
temperature.
4) Alimentary system and nutrition - Motility of GIT and GIT
hormones Digestion & absorption, concept of balanced diet, caloric requirements,
nutrients.
5) Reproductive physiology and endocrine system -
Hypothalamus, pituitary, Thyroid, Parathyroid, Adrenal and medullary hormones,
Male and Female reproductive system, Sex chromosomes, Barr bodies, sex
determination, sex differentiation, pregnancy, Lactation, Contraception.
6) Central nervous system and special senses - Action
potential, Muscle contraction, skeletal muscle, motor units, E.M.G. synapse,
neurotransmitters .receptors, tone posture, sensations. Reflexes, Tracts, UMN &
LMN, Spinal cord, Medulla oblongata, Pons, midbrain. Thalamic or Decorticate
animal, Posture & Equilibrium, vestibular apparatus, Thalamus, Hypothalamus,
Limbic system, Reticular formation, sleep wakeful cycle, E.E.G., Cerebellum,
Basal Ganglia, Cerebral Cortex, speech, Memory and Learning, reward and
punishment, Autonomic nervous system, CSF, blood brain barrier. Eye, optics,
Photochemistry of vision, Accommodation, Errors of refraction, Colour vision,
Visual pathway, Physics of sound, Audiometry, Auditory pathway, Sense of smell
and taste.
6) HUMAN BIOCHEMISTRY :
1) Chemistry of carbohydrates, lipids, proteins and
nucleic acids. enzymes, vitamins, nutrition, genetic code, protein biosynthesis.
2) Metabolism of carbohydrate, proteins, lipids, purines and
pyrimidines and related disorder.
3) Hormones, mineral and hemoglobin metabolism, porphyria,
jaunidce, liver function tests, kidney function tests and thyroid function
tests.
4) Detoxification mechanism, genetic engineering,
recombinanat technology and its application. Radioisotopes- uses and hazards.
Biochemistry of Cancer.
Section - C ( Marks : 50 )
7) PATHOLOGY :
1) General pathology : Causes of diseases. Cell injury.
Necrosis & gangrene. Inflammation. Regeneration and repair. Oedema. Shock.
Thrombosis. Embolism and Infarction. Haemorrhage. Mineral metabolism. Genetic
disorders. Hypersensitivity reactions. Autoimmune diseases. AIDS. Typhoid fever.
Syphilis, Tuberculosis. Leprosy. Fungal diseases. Malaria. Neoplasia.
2) Haematology - Hemopoiesis. anaemias. haemoglobinopathies.
haemorrhagic disorders. Leukaemias. Paraproteinemia. Blood groups. Blood
Transfusion.
3) Systemic pathology - Atherosclerosis. Ischaemic,
Congenital & Rheumatic heart diseases. Cardiomyopathies. Pneumonias. Lung
Abscess and Bronchiectasis. Emphysema. Occupational lung diseases. Tumours of
lung and pleura. Lesions of oral cavity and salivary glands. Gastritis and
Peptic Ulcer. Ulcers of Intestines. Idiopathic Inflammatory Bowel disease.
Tumours of upper GIT and lower GIT. Viral Hepatitis. Alcoholic liver disease.
Cirrhosis. Tumours of liver, Pancreas and gall bladder. Diabetes mellitus.
nephritis & GN. Nephrotic syndrome. Renal failure. Tumours of kidney, Pelvis,
testis, Prostate, Cervix, Uterus, Ovary, trophoblastic tissue, skin, soft
tissue, bone, cartilage and joints. Non-neoplastic and Neo-plastic lesions of
the breast, lymph nodes and Spleen. Lymphoma. lesions of bone and joints.
Inflammatory and neoplastic conditions of CNS. Lesions of Thyroid. Myopathies.
Clinical pathology: of jaundice. renal function tests. diabetes mellitus.
autopsy.
8) MICROBIOLOGY :
1) General Microbiology : Bacterial cell and its
organelles. Dark ground illumination, phase contrast and fluorescent microscopy,
electron microscopy. Physiology of bacteria. Culture media. Sterilization,